Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth.

ABSTRACT: The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast cancer, associated with poor outcome. Cyclin D1 transformed hTERT human fibroblast to a cancer-associated fibroblast phenotype. Stromal fibroblast expression of cyclin D1 (cyclin D1^Stroma) in vivo, enhanced breast epithelial cancer tumor growth, restrained apoptosis, and increased autophagy. Cyclin D1^Stroma had profound effects on the breast tumor microenvironment increasing the recruitment of F4/80⁺ and CD11b⁺ macrophages and increasing angiogenesis. Cyclin D1^Stroma induce

SUBMITTER: Pestell TG 

PROVIDER: S-EPMC5669846 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature