Postoperative seizure freedom does not normalize altered connectivity in temporal lobe epilepsy.

ABSTRACT:

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

Methods

Seventeen patients with intractable TLE who underwent epilepsy surgery with Engel class I outcome and 17 matched healthy controls took part in the study. The functional connectivity of a set of cognitive functional networks derived from typical cognitive tasks was assessed in patients, preoperatively

SUBMITTER: Maccotta L 

PROVIDER: S-EPMC5670008 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature