Antibiotics induce polarization of pleural macrophages to M2-like phenotype in patients with tuberculous pleuritis.

ABSTRACT: Pleural macrophages play critical roles in pathogenesis of tuberculous pleuritis, but very little is known about their response to anti-tuberculosis antibiotics treatment. Here, we examined whether and how pleural macrophages change in phenotype, transcription and function following antibiotics treatment in patients with tuberculous pleuritis. Results show pro-inflammatory cytokines were down-regulated significantly post antibiotic treatment in the pleural effusions and pleural macrophages up-regulated markers characteristic of M2 macrophages such as CD163 and CD206. Differential expression analysis of transcriptomes from four paired samples before and after treatment identified 230 treatment-specific responsive genes in pleural macrophages. Functional analysis identified interferon-relate

SUBMITTER: Wang S 

PROVIDER: S-EPMC5670217 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature