Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2⁺ breast cancer cells.

ABSTRACT:

Background

ERBB2 is overexpressed in up to 20-30% of human breast cancers (BCs), and it is associated with aggressive disease. Trastuzumab (Tz), a humanized monoclonal antibody, improves the prognosis associated with ERBB2-amplified BCs. However, the development of resistance remains a significant challenge. Carnosic acid (CA) is a diterpene found in rosemary and sage, endowed with anticancer properties. In this in vitro study, we have investigated whether Tz and CA have cooperative effects on cell survival of ERBB2 overexpressing (ERBB2⁺) cells and whether CA might restore Tz sensitivity in Tz-resistant cells.

Methods

We have studied BC cell migration and survival upon CA and Tz treatment. In particular, migration ability was assessed by transwell assay while cel

SUBMITTER: D'Alesio C 

PROVIDER: S-EPMC5670707 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature