Investigation of antiviral state mediated by interferon-inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells.

ABSTRACT:

Background

Endothelial cells are believed to play an important role in response to virus infection. Our previous microarray analysis showed that H9N2 virus infection and inactivated viral particle inoculation increased the expression of interferon-inducible transmembrane protein 1 (IFITM1) in human umbilical vein endothelial cells (HUVECs). In present study, we deeply investigated the expression patterns of IFITM1 and IFITM1-mediated antiviral response induced by H9N2 virus infection and inactivated viral particle inoculation in HUVECs. Epithelial cells that are considered target cells of the influenza virus were selected as a reference control.

Methods

First, we quantified the expression levels of IFITM1 in HUVECs induced by H9N2 virus infection or viral particle inoculatio

SUBMITTER: Feng B 

PROVIDER: S-EPMC5670731 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature