Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?

ABSTRACT:

Objective

Our previous genome-wide association study (GWAS) identified that the ABO rs633862 variant in chromosome 9q34.2 was associated with the risk of epithelial ovarian cancer (EOC) in Chinese Han women. The aim of the present study was to evaluate its prognostic effect on EOC.

Methods

A total of 669 EOC patients were enrolled for the genotyping of rs633862 variant in 9q34.2. We used Kaplan-Meier survival curves, univariate and multivariate Cox proportional hazard models to evaluate the association of rs633862 with overall survival (OS) in EOC patients.

Results

We found that rs633862 variant AG/GG genotypes were significantly associated with a longer OS by using univariate Cox proportional hazards regression analysis, compared with the rs633862 AA genotype

SUBMITTER: Jiang R 

PROVIDER: S-EPMC5671115 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature