Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele.

ABSTRACT:

Background

Cell-free RNA in amniotic fluid supernatant reflects developmental changes in gene expression in the living fetus, which includes genes that are specific to the central nervous system. Although it has been previously shown that central nervous system-specific transcripts are present in amniotic fluid supernatant, it is not known whether changes in the amniotic fluid supernatant transcriptome reflect the specific pathophysiologic condition of fetal central nervous system disorders. In myelomeningocele, there is open communication between the central nervous system and amniotic fluid.

Objectives

The purpose of this study was to identify molecular pathophysiologic changes and novel disease mechanisms that are specific to myelomeningocele by the analysis of amniotic f

SUBMITTER: Tarui T 

PROVIDER: S-EPMC5671344 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature