Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance.

ABSTRACT:

Background

Patients with food allergy produce high-titer IgE antibodies that bind to mast cells through FcεRI and trigger immediate hypersensitivity reactions on antigen encounter. Food-specific IgG antibodies arise in the setting of naturally resolving food allergy and accompany the acquisition of food allergen unresponsiveness in oral immunotherapy.

Objective

In this study we sought to delineate the effects of IgG and its inhibitory Fc receptor, FcγRIIb, on both de novo allergen sensitization in naive animals and on established immune responses in the setting of pre-existing food allergy.

Methods

Allergen-specific IgG was administered to mice undergoing sensitization and desensitization to the model food allergen ovalbumin. Cellular and molecular mechanisms were int

SUBMITTER: Burton OT 

PROVIDER: S-EPMC5671359 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature