Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.

ABSTRACT:

Importance

African Americans have the highest breast cancer mortality rate. Although racial difference in the distribution of intrinsic subtypes of breast cancer is known, it is unclear if there are other inherent genomic differences that contribute to the survival disparities.

Objectives

To investigate racial differences in breast cancer molecular features and survival and to estimate the heritability of breast cancer subtypes.

Design, setting, and participants

Among a convenience cohort of patients with invasive breast cancer, breast tumor and matched normal tissue sample data (as of September 18, 2015) were obtained from The Cancer Genome Atlas.

Main outcomes and measures

Breast cancer–free interval, tumor molecular features, and genetic variants.

Results

SUBMITTER: Huo D 

PROVIDER: S-EPMC5671371 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature