CDC42-related genes are upregulated in helper T cells from obese asthmatic children.

ABSTRACT:

Background

Pediatric obesity-related asthma is more severe and less responsive to medications than asthma in normal-weight children. Obese asthmatic children have nonatopic T_H1-polarized systemic inflammation that correlates with pulmonary function deficits, but the pathways underlying T_H1-polarized inflammation are not well understood.

Objective

We compared the CD4⁺ T-cell transcriptome in obese children with asthma with that in normal-weight children with asthma to identify key differentially expressed genes associated with T_H1-polarized inflammation.

Methods

CD4⁺ T-cell transcriptome-wide differential gene expression was compared between 21 obese and 21 normal-weight children by using directional RNA sequencing

SUBMITTER: Rastogi D 

PROVIDER: S-EPMC5671374 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature