Measuring brain synaptic vesicle protein 2A with positron emission tomography and [¹⁸F]UCB-H.

ABSTRACT:

Introduction

Brain distribution of synaptic vesicle protein 2A was measured with fluorine-18 UCB-H ([¹⁸F]UCB-H) and positron emission tomography (PET).

Methods

Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume.

Results

[¹⁸F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship.

Discussion

SUBMITTER: Bahri MA 

PROVIDER: S-EPMC5671624 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature