Characterization of APOE and TOMM40 allele frequencies in the Japanese population.

ABSTRACT:

Introduction

Dementia is one of the major health threats to our aging society, and Alzheimer's disease (AD) is the leading cause. In Japan, ∼15% of the elderly population has dementia. The apolipoprotein E (APOE) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (TOMM40) gene have been associated with the age of onset of AD. However, differences in allele frequencies of these markers in different ethnic populations are not well known.

Methods

Whole blood samples were collected from 300 Japanese subjects, and genomic DNA was extracted to determine APOE alleles and TOMM40 rs10524523 genotypes.

Results

Our results indicated that the APOE ε3-TOMM40'523 short haplotype is less frequent i

SUBMITTER: Nishimura A 

PROVIDER: S-EPMC5671626 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature