Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation.

ABSTRACT: Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level of morphology, anatomy, physiology and genomics, but few investigations focused on the roles of microRNA (miRNA) in high-altitude adaptation. We examined the differences in the miRNA transcriptomes of two representative hypoxia-sensitive tissues (heart and lung) between yak and cattle, two closely related species that live in high and low altitudes, respectively. In this study, we identified a total of 808 mature miRNAs, which corresponded to 715 pre-miRNAs in the two species. The further analysis revealed that both tissues showed relatively high correlation coefficient between yak and cattle, but a greater differentiation was present in lung than heart between the two species. In addition,

SUBMITTER: Guan J 

PROVIDER: S-EPMC5671665 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature