Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry.

ABSTRACT:

Background

Currently, there is limited knowledge about the genetics underlying pigmentary traits in East Asian populations. Here, we report the results of the first genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry.

Methods

We obtained quantitative skin pigmentation measures (M-index) in the inner upper arm of the participants using a portable reflectometer (N = 305). Quantitative measures of iris color (expressed as L*, a* and b* CIELab coordinates) were extracted from high-resolution iris pictures (N = 342). We also measured the color differences between the pupillary and ciliary regions of the iris (e.g., iris heterochromia). DNA samples were genotyped with Illumina's Infinium Multi-Ethnic Global A

SUBMITTER: Rawofi L 

PROVIDER: S-EPMC5671666 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature