Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.

ABSTRACT: Previous studies on changes in murine brain gene expression associated with the selection for ethanol preference have used F₂ intercross or heterogeneous stock (HS) founders, derived from standard laboratory strains. However, these populations represent only a small proportion of the genetic variance available in Mus musculus. To investigate a wider range of genetic diversity, we selected mice for ethanol preference using an HS derived from the eight strains of the collaborative cross. These HS mice were selectively bred (four generations) for high and low ethanol preference. The nucleus accumbens shell of naive S₄ mice was interrogated using RNA sequencing (RNA-Seq). Gene networks were constructed using the weighted gene coexpression network analysis assessing both c

SUBMITTER: Colville AM 

PROVIDER: S-EPMC5671806 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature