Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis.

ABSTRACT:

Background

The human immunity-related GTPase M (IRGM) is involved in regulating autophagy against invading pathogens. Recently, inconsistent results have been reported about the association between IRGM polymorphisms and tuberculosis risk in several studies.

Methods

We searched the PubMed, Embase, and Web of Knowledge, and extracted data from eligible articles to estimate the associations between IRGM polymorphisms (rs10065172, rs4958842, rs4859843, rs4859846, and rs72553867) and tuberculosis risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated using Review manager 5.3. The studies heterogeneity was assessed by Cochran Q test. Funnel plot, Begg test, and Egger linear regression test were used to evaluate the publication bias.

Results

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SUBMITTER: Xie H 

PROVIDER: S-EPMC5671819 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature