The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study.

ABSTRACT: Both genomics and environmental stressors play a significant role in increases in blood pressure (BP). In an attempt to further explain the hypertension (HTN) disparity among African Americans (AA), both genetic underpinnings (selected candidate genes) and stress due to perceived racial discrimination (as reported in the literature) have independently been linked to increased BP among AAs. Although Gene x Environment interactions on BP have been examined, the environmental component of these investigations has focused more on lifestyle behaviors such as smoking, diet, and physical activity, and less on psychosocial stressors such as perceived discrimination.The present study uses candidate gene analyses to identify the relationship between Everyday Discrimination (ED) and Major Life Discri

SUBMITTER: Taylor JY 

PROVIDER: S-EPMC5671860 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature