Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.

ABSTRACT:

Background

Although time-domain measures of heart rate variability (HRV) are used to estimate cardiac autonomic tone and disease risk in multiethnic populations, the genetic epidemiology of HRV in Hispanics/Latinos has not been characterized.

Objective

The purpose of this study was to conduct a genome-wide association study of heart rate (HR) and its variability in the Hispanic Community Health Study/Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Women's Health Initiative Hispanic SNP-Health Association Resource project (n = 13,767).

Methods

We estimated HR (bpm), standard deviation of normal-to-normal interbeat intervals (SDNN, ms), and root mean squared difference in successive, normal-to-normal interbeat intervals (RMSSD, ms) from resting, standard 12

SUBMITTER: Kerr KF 

PROVIDER: S-EPMC5671896 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature