Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.

ABSTRACT: Despite potent immunosuppression, clinical and biopsy confirmed acute renal allograft rejection (AR) still occurs in 10-15% of recipients, ~30% of patients demonstrate subclinical rejection on biopsy, and ~50% of them can show molecular inflammation, all which increase the risk of chronic dysfunction and worsened allograft outcomes. Mitochondria represent intracellular endogenous triggers of inflammation, which can regulate immune cell differentiation, and expansion and cause antigen-independent graft injury, potentially enhancing the development of acute rejection. In the present study, we investigated the role of mitochondrial DNA encoded gene expression in biopsy matched peripheral blood (PB) samples from kidney transplant recipients. Quantitative PCR was performed in 155 PB samples fro

SUBMITTER: Roedder S 

PROVIDER: S-EPMC5671971 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature