A Comprehensive, Open-source Platform for Mass Spectrometry-based Glycoproteomics Data Analysis.

ABSTRACT: Glycosylation is among the most abundant and diverse protein post-translational modifications (PTMs) identified to date. The structural analysis of this PTM is challenging because of the diverse monosaccharides which are not conserved among organisms, the branched nature of glycans, their isomeric structures, and heterogeneity in the glycan distribution at a given site. Glycoproteomics experiments have adopted the traditional high-throughput LC-MSⁿ proteomics workflow to analyze site-specific glycosylation. However, comprehensive computational platforms for data analyses are scarce. To address this limitation, we present a comprehensive, open-source, modular software for glycoproteomics data analysis called GlycoPAT (GlycoProteomics Analysis Toolbox; freely available from www.Vi

SUBMITTER: Liu G 

PROVIDER: S-EPMC5672007 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature