CD40L Expression Allows CD8⁺ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells.

ABSTRACT: CD8⁺ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation. Although CD40L-mediated CD40 licensing of dendritic cells (DCs) by CD4⁺ T cells is known to be necessary for the generation of a robust CD8⁺ T cell response, the contribution of CD8⁺ T cell-expressed CD40L on DC licensing is less clear. We have previously shown that CD8⁺ T cells are able to induce the production of IL-12 p70 by DCs in a CD40L-dependent manner, providing some evidence that CD8⁺ T cell-mediated activation of DCs is possible. To better understand the role of CD40L on CD8⁺ T cell responses, we generated and characterized CD40L-expressing CD

SUBMITTER: Tay NQ 

PROVIDER: S-EPMC5672143 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature