In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera.

ABSTRACT: Canine cognitive dysfunction (CCD) is an age-dependent neurodegenerative condition characterised by changes in decline in learning and memory patterns. The neurodegenerative features of CCD in ageing dogs and cats are similar to human ageing and Alzheimer's disease (AD). Discovering neuroprotective disease-modifying therapies against CCD and AD is a major challenge. Strong evidence supports the role of amyloid β peptide deposition and oxidative stress in the pathophysiology of CCD and AD. In both the human and canine brain, oxidative damage progressively increases with age. Dietary antioxidants from natural sources hold a great promise in halting the progression of CCD and AD. Withania somnifera (WS), an Ayurvedic tonic medicine, also known as 'Indian ginseng' or ashwagand

SUBMITTER: Singh M 

PROVIDER: S-EPMC5672322 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature