Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue.

ABSTRACT: Optimising cell/tissue constructs so that they can be successfully accepted and integrated within a host body is essential in modern tissue engineering. To do this, adult stem cells are frequently utilised, but there are many aspects of their environment in vivo that are not completely understood. There is evidence to suggest that circadian rhythms and daily circadian temporal cues have substantial effects on stem cell activation, cell cycle, and differentiation. It was hypothesised that the circadian rhythm in human adult stem cells differs depending on the source of tissue and that different entraining signals exert differential effects depending on the anatomical source. Dexamethasone and rhythmic mechanical stretch were used to synchronise stem cells derived from the bone marrow

SUBMITTER: Rogers EH 

PROVIDER: S-EPMC5672638 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature