Automated MicroSPECT/MicroCT Image Analysis of the Mouse Thyroid Gland.

ABSTRACT:

Background

The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve ¹³¹I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer.

Methods

A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post injection of ¹²³I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively. FVB/N mice with normal thyroid glands and TgBRAF^V600E mice with thyroid tumors

SUBMITTER: Cheng P 

PROVIDER: S-EPMC5672640 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature