Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction.

ABSTRACT: A variety of hydrogels have been synthesized for controlling the release of signaling molecules in applications such as drug delivery and regenerative medicine. However, it remains challenging to synthesize hydrogels with the ability to control the release of signaling molecules sequentially or periodically under physiological conditions as living cells do in response to the variation of metabolism. The purpose of this work was to study a novel biomimetic hydrogel system with the ability of recapitulating the procedure of cellular signal transduction and controlling the sequential release of signaling molecules under physiological conditions. In the presence of a small chemical, the signaling molecule is regulated to change from a DNA-bound state to a free state and the freed signaling mol

SUBMITTER: Lai J 

PROVIDER: S-EPMC5672785 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature