Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8⁺ T cells.

ABSTRACT: Designing CD8⁺ T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1γ as CD8⁺ T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE-1γ, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor control in mice vaccinated with this vector can be further enhanced by blocking the immune checkpoints TIGIT and PD-1. CMV vector expressing RAE-1γ potentiated expansion of KLRG1⁺ CD8⁺ T cells with enhanced effector properties. This vaccination was even more e

SUBMITTER: Trsan T 

PROVIDER: S-EPMC5672794 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature