Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort study.

ABSTRACT:

Background

Acute pulmonary exacerbations are associated with progressive lung function decline and increased mortality in cystic fibrosis. The role of pulmonary vascular disease in pulmonary exacerbations is unknown. We aimed to assess the association between pulmonary artery enlargement (defined as pulmonary artery diameter to ascending aorta diameter [PA:A] ratio >1), a marker of pulmonary vascular disease, and exacerbations.

Methods

In this cohort study, we used clinical, CT imaging, and prospective exacerbation data from a previous prospective clinical trial (derivation cohort) and from The Prince Charles Hospital (TPCH; Brisbane, QLD, Australia) cystic fibrosis registry (validation cohort). In our derivation cohort, we included adults aged 18 years or older with cystic

SUBMITTER: Wells JM 

PROVIDER: S-EPMC5672808 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature