Associations of Annual Ambient Fine Particulate Matter Mass and Components with Mitochondrial DNA Abundance.

ABSTRACT:

Background

Fine particulate matter (PM2.5) represents a mixture of components with potentially different toxicities. However, little is known about the relative effects of PM2.5 mass and PM2.5 components on mitochondrial DNA (mtDNA) abundance, which may lie on the pathway of PM2.5-associated disease.

Methods

We studied 646 elderly male participants in the Normative Aging Study from Greater Boston to investigate associations of long-term exposure to PM2.5 mass and PM2.5 components with mtDNA abundance. We estimated concentrations of pollutants for the 365-day preceding examination at each participant's address using spatial- and temporal-resolved chemical transport models. We measured blood mtDNA abundance using RT-PCR. We applied a shrinkage and selection method (adaptive LA

SUBMITTER: Peng C 

PROVIDER: S-EPMC5672826 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature