Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer.

ABSTRACT:

Background

Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer.

Methods

This single-blinded, two-arm randomised controlled trial explored outcomes of a presurgical weight loss intervention (WLI) that promoted ∼1 kg per week loss via caloric restriction and increased physical activity (PA). Forty overweight/obese men with clinically confirmed prostate cancer were randomised to the WLI presurgery or to a control arm; changes in weight, body composition, quality-of-life, circulating biomarkers, gene expression, and immunohistochemical markers in tumour and benign prostatic tissue were evaluated.

Results</

SUBMITTER: Demark-Wahnefried W 

PROVIDER: S-EPMC5672928 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature