Ffar2 expression regulates leukaemic cell growth in vivo.

ABSTRACT:

Background

Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also influences leukaemia cell growth in vivo.

Methods

Bcr-Abl-expressing BaF cells were used as a leukaemia model and the role of Ffar2 was evaluated in Balb/c mice after lentiviral shRNA transduction.

Results

Our data formally establish that reduced leukaemic cell proliferation is associated with increased Ffar2 expression in vivo and in vitro. Going beyond association, we point out that decreasing Ffar2 expression fosters cancer cell growth in vitro and in vivo.

Conclusions

Our data demonstrate the role of Ffar2 in the control of leukaemic cell p

SUBMITTER: Bindels LB 

PROVIDER: S-EPMC5672929 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature