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Clinically significant mutations in HIV-infected patients with lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is a major cause of death in HIV-infected (HIV+) persons. In this study, we compared the prevalence of tumour EGFR and KRAS mutations in a cohort of lung adenocarcinoma patients by HIV status.

Methods

We collected data from 55 HIV+ patients with lung adenocarcinoma matched to 136 uninfected comparators. We compared the prevalence of EGFR and KRAS mutations by HIV status. We then compared survival by HIV status and by cancer mutation status among HIV+ subjects.

Results

Presence of KRAS and EGFR genetic alterations did not vary by HIV status (all P>0.1). There was no difference in overall survival by HIV status or by mutation status among HIV+ subjects.

Conclusions

We found no major differences in the prevalence of EGFR or KRAS lung adenocarcinoma mutations by HIV status, suggesting that mutational testing should be conducted similarly regardless of the HIV status.

SUBMITTER: Thaler J

PROVIDER: S-EPMC5672933 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Clinically significant mutations in HIV-infected patients with lung adenocarcinoma.

Thaler Jonathan J Sigel Carlie C Beasley Mary Beth MB Wisnivesky Juan J Crothers Kristina K Bauml Joshua J Hysell Kristen K Emu Brinda B Borsu Laetitia L Sigel Keith K

British journal of cancer 20170921 9

<h4>Background</h4>Lung cancer is a major cause of death in HIV-infected (HIV+) persons. In this study, we compared the prevalence of tumour EGFR and KRAS mutations in a cohort of lung adenocarcinoma patients by HIV status.<h4>Methods</h4>We collected data from 55 HIV+ patients with lung adenocarcinoma matched to 136 uninfected comparators. We compared the prevalence of EGFR and KRAS mutations by HIV status. We then compared survival by HIV status and by cancer mutation status among HIV+ subject ...[more]

PMID: 28934759

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