Neurogenesis in the olfactory bulb induced by paced mating in the female rat is opioid dependent.

ABSTRACT: The possibility to control the rate of sexual stimulation that the female rat receives during a mating encounter (pacing) increases the number of newborn neurons that reach the granular layer of the accessory olfactory bulb (AOB). If females mate repeatedly, the increase in the number of neurons is observed in other regions of the AOB and in the main olfactory bulb (MOB). It has also been shown that paced mating induces a reward state mediated by opioids. There is also evidence that opioids modulate neurogenesis. In the present study, we evaluated whether the opioid receptor antagonist naloxone (NX) could reduce the increase in neurogenesis in the AOB induced by paced mating. Ovariectomized female rats were randomly divided in 5 different groups: 1) Control (not mated) treated with saline,

SUBMITTER: Santoyo-Zedillo M 

PROVIDER: S-EPMC5673160 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature