Helicobacter pylori bab characterization in clinical isolates from Bhutan, Myanmar, Nepal and Bangladesh.

ABSTRACT:

Background

Helicobacter pylori BabA is an important outer membrane protein that involves in the attachment to the gastric mucosa and enhances the virulence property of the bacterium. This study was aimed to characterize the bab genotypes, to evaluate its association with cagA, vacA and clinical diseases as well as degree of gastric inflammation.

Methods

H. pylori isolates from four countries were subjected for the characterization of bab. The locus specific forward and bab specific reverse primers were used to get the specific products by PCR, which could distinguish the three locus (A, B and C). The histological activities were evaluated according to the Updated Sydney system.

Result

In patients from high risk countries (Bhutan and Myanmar) relatively higher frequenc

SUBMITTER: Ansari S 

PROVIDER: S-EPMC5673166 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature