Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction.

ABSTRACT:

Background

Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes.

Objective

Our study evaluates the relationship between autonomic nervous system (ANS) and contact/complement system activation.

Methods

Twenty-three HAE patients (6 males, mean age 47.5±11.4 years) during remission and 24 healthy controls (8 males, mean age 45.3±10.6 years) were studied. ECG, beat-by-beat blood pressure, respiratory activity were continuously recorded during rest (10') and 75-degrees-head-up tilt (10'). C1-INH, C4, cleaved high molecular weight kininogen (cHK) were assessed; in 16 patients and 11 controls plasma catecholamines were also evaluated. Spectral analysis of heart rate variability allowed extraction

SUBMITTER: Wu MA 

PROVIDER: S-EPMC5673184 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature