Maternal immune activation in rats produces temporal perception impairments in adult offspring analogous to those observed in schizophrenia.

ABSTRACT: The neurophysiology underlying temporal perception significantly overlaps with areas of dysfunction identified in schizophrenia. Patients commonly exhibit distorted temporal perception, which likely contributes to functional impairments. Thus, study of temporal perception in animal models of the disease may help to understand both cognitive and neurobiological factors involved in functional impairments in patients. As maternal immune activation (MIA) has been shown to be a significant etiological risk factor in development of schizophrenia and other developmental psychiatric diseases, we tested interval timing in a rat model of MIA that has previously been shown to recapitulate several behavioural and neurophysiological impairments observed in the disease. Rats were tested on a temporal-bi

SUBMITTER: Deane AR 

PROVIDER: S-EPMC5673217 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature