Fetal and Maternal Genetic Variants Influencing Neonatal Vitamin D Status.

ABSTRACT:

Objective

Several genetic polymorphisms determine vitamin D status. We aimed to estimate the strength of association of established 25-hydroyxvitamin D (25OHD)-associated variants in the mother and in the fetus, with 25OHD concentration in newborn umbilical cord plasma.

Methods

We randomly selected 578 mother and child dyads from the prospective Norwegian Mother and Child Cohort study. 25OHD was assayed in maternal samples taken shortly after delivery and in cord samples. We genotyped the mother and child for single nucleotide polymorphisms in or near GC, DHCR7, CYP2R1, and CYP24A1, previously confirmed to be associated with 25OHD, and computed genetic risk score (GRS). The genetic associations were replicated in an independent sample of 594 subjects.

Results

Although

SUBMITTER: Stordal K 

PROVIDER: S-EPMC5673272 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature