The Association of Estrogen Receptor-β Gene Variation With Salt-Sensitive Blood Pressure.

ABSTRACT:

Context

Hypertension in young women is uncommon compared with young men and older women. Estrogen appears to protect most women against hypertension, with incidence increasing after menopause. Because some premenopausal women develop hypertension, estrogen may play a different role in these women. Genetic variations in the estrogen receptor (ER) are associated with cardiovascular disease. ER-β, encoded by ESR2, is the ER predominantly expressed in vascular smooth muscle.

Objective

To determine an association of single nucleotide polymorphisms in ESR2 with salt sensitivity of blood pressure (SSBP) and estrogen status in women.

Methods

Candidate gene association study with ESR2 and SSBP conducted in normotensive and hypertensive women and men in two cohorts: Internation

SUBMITTER: Manosroi W 

PROVIDER: S-EPMC5673274 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature