Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.

ABSTRACT: Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of AMPARs. The preferential trafficking of calcium-permeable versus impermeable AMPARs can result in disruptions of [Ca²⁺ ]_i and alter cellular functions. In striatal neurodegenerative diseases, changes in [Ca²⁺ ]_i and L-type voltage-gated calcium channels (VGCCs) have been reported. Therefore, this study sought to determine whether a proinflammatory environment alters AMPA-stimulated [Ca²⁺ ]_i through calcium-permeable AMPARs and/or L-type VGCCs in dopamine-2- and dopamine-1-expressing striatal spiny projection neurons (D2 and D

SUBMITTER: Winland CD 

PROVIDER: S-EPMC5673553 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature