Surgical Antibiotic Prophylaxis and Risk for Postoperative Antibiotic-Resistant Infections.

ABSTRACT:

Background

Antibiotic-resistant infections have high rates of morbidity and mortality, and exposure to antibiotics is the crucial risk factor for development of antibiotic resistance. If surgical antibiotic prophylaxis (SAP) increases risk for antibiotic-resistant infections, prophylaxis may cause net harm, even if it decreases overall infection rates.

Study design

This retrospective cohort study included adults who underwent elective surgical procedures and developed infections within 30 postoperative days. Procedures from multiple disciplines were included if SAP was considered discretionary by current guidelines. Postoperative antibiotic-resistant infections were defined as positive culture results from any site within 30 postoperative days, showing intermediate or nonsus

SUBMITTER: Cohen ME 

PROVIDER: S-EPMC5673556 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature