Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration.

ABSTRACT:

Introduction

Human cartilage is an avascular tissue with limited capacity for repair. By contrast, certain lizards are capable of musculoskeletal tissue regeneration following tail loss throughout all stages of their lives. This extraordinary ability is the result of a complex process in which a blastema forms and gives rise to the tissues of the regenerate. Blastemal cells have been shown to originate either from dedifferentiated tissues or from existing progenitor cells in various species, but their origin has not been determined in lizards. As reptiles, lizards are the closest relatives to mammals with enhanced regenerative potential, and the origin of blastemal cells has important implications for the regenerative process. Hence, the aim of this study is to determine the cellul

SUBMITTER: Londono R 

PROVIDER: S-EPMC5673626 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature