Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases.

ABSTRACT: Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2⁺ and triple negative (TN) subtypes. Mechanistic insight into the pathophysiology of brain metastases and preclinical validation of therapies has relied almost exclusively on intracardiac injection of brain-homing cells derived from highly aggressive TN MDA-MB-231 and HER2⁺ BT474 breast cancer cell lines. Yet, these well characterized models are far from representing the tumor heterogeneity observed clinically and, due to their fast progression in vivo, their suitability to validate therapies for established brain metastasis remains limited. The goal of this study was to develop and characterize novel human brain metastasis breast cancer patient-derived xenog

SUBMITTER: Contreras-Zarate MJ 

PROVIDER: S-EPMC5673842 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature