Metabolic characteristics of programmed cell death-ligand 1-expressing lung cancer on ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography.

ABSTRACT: Programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) have been identified as novel targets of immunotherapy of lung cancer. In present study, we evaluated the metabolic characteristics of lung cancer by using ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸ F-FDG PET/CT) with regard to PD-L1 protein expression. PD-L1 protein expression was evaluated by immunohistochemistry with the antibody clone SP142 in 579 surgically resected primary lung cancer patients. Cases with less than 5% tumor membrane staining were considered negative. We examined the association between the frequency of PD-L1 protein expression and the maximum standardized uptake value (SUVmax) in preoperative ¹⁸ F-FDG PET/CT. The cut-off values

SUBMITTER: Takada K 

PROVIDER: S-EPMC5673920 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature