Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding.

ABSTRACT: Medial septal inputs to the hippocampal system are crucial for aspects of temporal and spatial processing, such as theta oscillations and grid cell firing. However, the precise contributions of the medial septum's cholinergic neurones to these functions remain unknown. Here, we recorded neuronal firing and local field potentials from the medial entorhinal cortex of freely foraging mice, while modulating the excitability of medial septal cholinergic neurones. Alteration of cholinergic activity produced a reduction in the frequency of theta oscillations, without affecting the slope of the non-linear theta frequency vs running speed relationship observed. Modifying septal cholinergic tone in this way also led mice to exhibit behaviours associated with novelty or anxiety. However, grid cell fi

SUBMITTER: Carpenter F 

PROVIDER: S-EPMC5673944 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature