Proteomic analysis reveals an impaired Ca²⁺/AQP5 pathway in the submandibular gland in hypertension.

ABSTRACT: Hypertension is a systemic disorder that affects numerous physiological processes throughout the body. Improper sodium transport is a common comorbidity of hypertension, and sodium transport is also critical for maintaining the secretion of submandibular glands, whether the function of submandibular glands is affected by hypertension remains unclear. To determine whether hypertension induces changes in the protein expression of submandibular glands, we compared the proteome of submandibular glands from 14-week-old spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats using LC-MS/MS. The results revealed that 95 proteins displayed different levels of expression between the submandibular glands from the SHRs and WKYs. Among these, 35 proteins were more abundant, and 60 proteins w

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5674029 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature