Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer.

ABSTRACT:

Background

The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver molecules for LVI remains a challenging task. Large-scale transcriptomic profiling of histologically validated LVI can potentially identify genes that regulate LVI.

Methods

Integrative bio-informatics analyses of the METABRIC study were performed utilising a subset of strictly defined LVI using histological and immunohistochemical (IHC) criteria. ARHGAP18 was among the top differentially expressed genes between LVI+ and LVI- BC with a 1.8-fold change. The prognostic impact of ARHGAP18 gene expression was assessed in the METABRIC data set (n=1980) and externally validated using the online BC gene express

SUBMITTER: Aleskandarany MA 

PROVIDER: S-EPMC5674094 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature