MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.

ABSTRACT:

Background

Metastasis accounts for the most lethal reason for the death of ovarian cancer patients, but remains largely untreated. Epithelial-mesenchymal transition (EMT) is critical for the conversion of early-stage ovarian tumours into metastatic malignancies. Thus the exploration of the signalling pathways promoting EMT would open potential opportunities for the treatment of metastatic ovarian cancer. Herein, the putative role of MDM2 in regulating EMT and metastasis of ovarian cancer SKOV3 cells was investigated.

Methods

The regulatory effects by MDM2 on cell motility was emulated by wound-healing and transwell assays. The effects on EMT transition and Smad pathway were studied by depicting the expression levels of epithelial marker E-cadherin as well as key components o

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5674096 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature