Circulating resistin levels and risk of multiple myeloma in three prospective cohorts.

ABSTRACT:

Background

Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case-control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, this association has not been investigated prospectively.

Methods

We measured resistin concentrations for pre-diagnosis peripheral blood samples from 178 MM cases and 358 individually matched controls from three cohorts participating in the MM cohort consortium.

Results

In overall analyses, higher resistin levels were weakly associated with reduced MM risk. For men, we observed a statistically significant inverse association between resistin levels and MM (odds ratio, 0.44; 95% confidence interval (CI) 0.24-0.83 and 0.54; 95% CI 0.29-0.99, for the third

SUBMITTER: Santo L 

PROVIDER: S-EPMC5674102 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature