Self-quenched ferrocenyl diketopyrrolopyrrole organic nanoparticles with amplifying photothermal effect for cancer therapy.

ABSTRACT: Organic nanoparticles (NPs) with near-infrared absorbance possess high photothermal conversion (PTC) efficiency and an excellent photoacoustic signal, presenting a great prospect for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Herein, a novel diketopyrrolopyrrole derivative (DPPCN-Fc) is synthesized for use as a PTT agent with PAI performance. Due to photo-induced electron transfer (PET), the two flanked ferrocene moieties significantly quench the radiative decay and intersystem crossing process, resulting in an enhanced nonradiative transition, and an amplifying photothermal effect is observed. Exposing the DPPCN-Fc NP aqueous dispersion (100 μg mL-1) to 730 nm (1.0 W cm-2) laser radiation results in a temperature elevation of 33.4 °C within 10 min and the PTC efficienc

SUBMITTER: Liang P 

PROVIDER: S-EPMC5674203 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature