Nanofiber-based sutures induce endogenous antimicrobial peptide.

ABSTRACT:

Aim

The aim of this study was to develop nanofiber-based sutures capable of inducing endogenous antimicrobial peptide production.

Methods

We used co-axial electrospinning deposition and rolling to fabricate sutures containing pam3CSK4 peptide and 25-hydroxyvitamin D₃ (25D₃).

Results

The diameters and mechanical properties of the sutures were adjustable to meet the criteria of United States Pharmacopeia designation. 25D₃ exhibited a sustained release from nanofiber sutures over 4 weeks. Pam3CSK4 peptide also showed an initial burst followed by a sustained release over 4 weeks. The co-delivery of 25D₃ and pam3CSK4 peptide enhanced cathelicidin antimicrobial peptide production from U937 cells and keratinocytes compared with 25D

SUBMITTER: Chen S 

PROVIDER: S-EPMC5674207 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature