Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans.

ABSTRACT:

Aim

To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits.

Methods

We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC, in blood DNA using the Infinium HumanMethylation450 (n = 100, a Korean COPD cohort).

Results

We found one significant DMP (cg03559389, DIP2C) and 104 significant DMRs after multiple-testing correction. Of these, 34 DMRs mapped to genes differential expressed with respect to the same trait. Five of the genes were associated with more than two traits: CTU2, USP36, ZNF516, KLK10 and CPT1B.

Conclusion

We identified novel diff

SUBMITTER: Lee MK 

PROVIDER: S-EPMC5674213 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature